The results showed that glutathione decreased the toxicity of chemotherapeutic drugs with clinical significance. However, it is still necessary to carry out the appropriate scale of research on various types of tumors to verify that the best drug delivery scheme has not yet been determined, but the use of cisplatin infusion 30min, and in cisplatin before the drug delivery of glutathione 15min, then 72h intramuscular injection of the drug is worth further study.